Case Study: Rapid Complete Recovery From An Autism Spectrum Disorder After Treatment of Aspergillus With The Antifungal Drugs Itraconazole And Sporanox.
Identifieur interne : 000344 ( Main/Exploration ); précédent : 000343; suivant : 000345Case Study: Rapid Complete Recovery From An Autism Spectrum Disorder After Treatment of Aspergillus With The Antifungal Drugs Itraconazole And Sporanox.
Auteurs : Sidney Baker [États-Unis] ; William Shaw [États-Unis]Source :
- Integrative medicine (Encinitas, Calif.) [ 1546-993X ] ; 2020.
Abstract
Context
A child with symptoms placing him within the autism spectrum and with urine biochemical markers consistent with fungal (
Objective
The child's physician (Baker) wished to try a more potent antifungal therapy, itraconazole, in an attempt to reverse the child's autism since itraconazole is an especially effective agent against
Setting
The child was treated as an outpatient by the physician who had first diagnosed the child with an autism spectrum disorder.
Participant
A child with an autism spectrum disorder.
Intervention
The major intervention was increasing doses of the antifungal drug itraconazole. However, the Sporanox
Results
The child had a complete recovery from all the symptoms of autism and in addition developed excellent academic, athletic, and musical skills. The recovery coincided with a marked reduction of urine markers of
Conclusions
Escalation of the dose of itraconazole resulted in a complete loss of all symptoms of autism over the course of three months. This rapid complete reversal of autism is consistent with several articles proposing mold in general and
PubMed: 33132781
PubMed Central: PMC7572136
Affiliations:
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However, the Sporanox</p></div><div type="abstract" xml:lang="en"><p><b>Results</b></p><p>The child had a complete recovery from all the symptoms of autism and in addition developed excellent academic, athletic, and musical skills. The recovery coincided with a marked reduction of urine markers of </p></div><div type="abstract" xml:lang="en"><p><b>Conclusions</b></p><p>Escalation of the dose of itraconazole resulted in a complete loss of all symptoms of autism over the course of three months. This rapid complete reversal of autism is consistent with several articles proposing mold in general and </p></div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">33132781</PMID><DateRevised><Year>2020</Year><Month>11</Month><Day>03</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1546-993X</ISSN><JournalIssue CitedMedium="Print"><Volume>19</Volume><Issue>4</Issue><PubDate><Year>2020</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Integrative medicine (Encinitas, Calif.)</Title><ISOAbbreviation>Integr Med (Encinitas)</ISOAbbreviation></Journal><ArticleTitle>Case Study: Rapid Complete Recovery From An Autism Spectrum Disorder After Treatment of Aspergillus With The Antifungal Drugs Itraconazole And Sporanox.</ArticleTitle><Pagination><MedlinePgn>20-27</MedlinePgn></Pagination><Abstract><AbstractText Label="Context" NlmCategory="UNASSIGNED">A child with symptoms placing him within the autism spectrum and with urine biochemical markers consistent with fungal (<i>Aspergillus</i>) colonization of the gastrointestinal tract was first treated with the antifungal probiotic <i>Saccharomyces boulardii.</i> A dramatic Herxheimer reaction provided strong clinical indications that mold colonization might be a factor in causing autism in this child.</AbstractText><AbstractText Label="Objective" NlmCategory="UNASSIGNED">The child's physician (Baker) wished to try a more potent antifungal therapy, itraconazole, in an attempt to reverse the child's autism since itraconazole is an especially effective agent against <i>Aspergillus</i> species.</AbstractText><AbstractText Label="Setting" NlmCategory="UNASSIGNED">The child was treated as an outpatient by the physician who had first diagnosed the child with an autism spectrum disorder.</AbstractText><AbstractText Label="Participant" NlmCategory="UNASSIGNED">A child with an autism spectrum disorder.</AbstractText><AbstractText Label="Intervention" NlmCategory="UNASSIGNED">The major intervention was increasing doses of the antifungal drug itraconazole. However, the Sporanox<sup>®</sup> brand of itraconazole gave the best results. The child was monitored twice weekly with liver function tests which remained normal throughout the therapy.</AbstractText><AbstractText Label="Results" NlmCategory="UNASSIGNED">The child had a complete recovery from all the symptoms of autism and in addition developed excellent academic, athletic, and musical skills. The recovery coincided with a marked reduction of urine markers of <i>Aspergillus</i> colonization.</AbstractText><AbstractText Label="Conclusions" NlmCategory="UNASSIGNED">Escalation of the dose of itraconazole resulted in a complete loss of all symptoms of autism over the course of three months. This rapid complete reversal of autism is consistent with several articles proposing mold in general and <i>Aspergillus</i> specifically as a potential major cause of autism.</AbstractText><CopyrightInformation>Copyright © 2020 InnoVision Professional Media Inc.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Baker</LastName><ForeName>Sidney</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Private practice in Sag Harbor, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shaw</LastName><ForeName>William</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>The Great Plains Laboratory in Lenexa, Kansas.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Integr Med (Encinitas)</MedlineTA><NlmUniqueID>101196303</NlmUniqueID><ISSNLinking>1546-993X</ISSNLinking></MedlineJournalInfo></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pmc-release"><Year>2021</Year><Month>08</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>11</Month><Day>2</Day><Hour>6</Hour><Minute>14</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>11</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>11</Month><Day>3</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33132781</ArticleId><ArticleId IdType="pii">imcj-19-20</ArticleId><ArticleId IdType="pmc">PMC7572136</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Arch Pediatr Adolesc Med. 2008 Nov;162(11):1026-34</Citation><ArticleIdList><ArticleId IdType="pubmed">18981350</ArticleId></ArticleIdList></Reference><Reference><Citation>mSphere. 2018 Mar 28;3(2):</Citation><ArticleIdList><ArticleId IdType="pubmed">29600282</ArticleId></ArticleIdList></Reference><Reference><Citation>Glob Adv Health Med. 2014 May;3(3):92-101</Citation><ArticleIdList><ArticleId IdType="pubmed">24944876</ArticleId></ArticleIdList></Reference><Reference><Citation>J Autism Dev Disord. 2008 Mar;38(3):481-8</Citation><ArticleIdList><ArticleId IdType="pubmed">17619130</ArticleId></ArticleIdList></Reference><Reference><Citation>Transl Psychiatry. 2014 Feb 11;4:e360</Citation><ArticleIdList><ArticleId IdType="pubmed">24518398</ArticleId></ArticleIdList></Reference><Reference><Citation>Toxins (Basel). 2016 Jul 04;8(7):</Citation><ArticleIdList><ArticleId IdType="pubmed">27384585</ArticleId></ArticleIdList></Reference><Reference><Citation>J Med Case Rep. 2014 Dec 05;8:407</Citation><ArticleIdList><ArticleId IdType="pubmed">25476874</ArticleId></ArticleIdList></Reference><Reference><Citation>Sci Rep. 2019 Sep 16;9(1):13401</Citation><ArticleIdList><ArticleId IdType="pubmed">31527606</ArticleId></ArticleIdList></Reference><Reference><Citation>J Autism Dev Disord. 1985 Dec;15(4):389-97</Citation><ArticleIdList><ArticleId IdType="pubmed">4077813</ArticleId></ArticleIdList></Reference><Reference><Citation>Toxicol Ind Health. 2009 Oct-Nov;25(9-10):703-10</Citation><ArticleIdList><ArticleId IdType="pubmed">19793774</ArticleId></ArticleIdList></Reference><Reference><Citation>J Rheumatol. 1990 Mar;17(3):407-12</Citation><ArticleIdList><ArticleId IdType="pubmed">2185361</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Kansas</li><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Baker, Sidney" sort="Baker, Sidney" uniqKey="Baker S" first="Sidney" last="Baker">Sidney Baker</name></region><name sortKey="Shaw, William" sort="Shaw, William" uniqKey="Shaw W" first="William" last="Shaw">William Shaw</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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